Genetics of Human and Canine Dilated Cardiomyopathy

Table 1

Genes with mutations associated with DCM in humans.

Gene	Location/role	Reference
ABCC9	Calcium/sodium-handling	[81]
ACTC1	Sarcomere & cytoskeleton	[82]
ACTN2	Sarcomere & cytoskeleton	[83]
ANKRD1	Sarcomere & transcription factor	[84]
BAG3	Sarcomere	[85–87]
CAV3	Other	[88]
CHRM2	Other	[89]
CRYAB	Cytoskeleton	[90]
CSRP3	Sarcomere & cytoskeleton	[83]
CTF1	Other	[91]
DES	Cytoskeleton	[92, 93]
DMD	Cytoskeleton	[94, 95]
DNAJC19	Other	[96]
DOLK	Other	[97]
DSC2	Desmosome	[98]
DSG2	Desmosome	[99]
DSP	Desmosome	[100]
EYA4	Other	[101]
FHL2	Sarcomere & cytoskeleton	[102]
FKTN	Cytoskeleton	[103]
FKRP	Cytoskeleton	[104]
FOXD4	Transcription factor	[105]
GATAD1	Other	[106]
HCG22	Other	[107]
HLA-DQB1	Other	[108]
HSPB7	Other	[109]
ILK	Cytoskeleton	[110]
LAMA2	Other	[111]
LAMA4	Cytoskeleton	[110]
LAMP2	Other	[112]
LDB3	Sarcomere & cytoskeleton	[113]
LMNA	Nuclear envelope	[114]
MURC	Other	[115]
MYBPC3	Sarcomere	[116, 117]
MYH6	Sarcomere	[117, 118]
MYH7	Sarcomere	[116]
MYPN	Cytoskeleton	[119]
NEBL	Sarcomere	[120]
NEXN	Sarcomere	[121]
NOS3	Other	[122]
PKP2	Desmosome	[98]
PLN	Calcium/sodium-handling	[123]
PRDM16	Transcription factor	[124]
PSEN1	Other	[125]
PSEN2	Other	[125]
RBM20	Other	[126]
RYR2	Calcium/sodium-handling	[127]
SCN5A	Calcium/sodium-handling	[128]
SDHA	Other	[129]
SGCD	Cytoskeleton	[130]
SYNE1	Nuclear envelope	[131]
TAZ	Other	[132]
TBX20	Transcription factor	[133]
TCAP	Sarcomere & cytoskeleton	[134]
TMPO	Nuclear envelope	[135]
TNNC1	Sarcomere	[117]
TNNI3	Sarcomere	[136]
TNNT2	Sarcomere	[137]
TPM1	Sarcomere	[117]
TXNRD2	Other	[138]
TTN	Sarcomere & cytoskeleton	[139]
VCL	Sarcomere & cytoskeleton	[140]
ZBTB17	Other	[141]