Differential MicroRNA Analyses of Burkholderia pseudomallei- and Francisella tularensis-Exposed hPBMCs Reveal Potential Biomarkers

Figure 2

Heatmap of 36 miRNA species tested in the miScript qPCR assay. The qPCR fold changes were plotted for three time points (t30, t60, and t120) for E. coli- (ec-), B. pseudomallei- (bp-), and F. tularensis- (ft-) exposed hPBMCs. The miRNA species that show either decreasing or increasing expression with statistical significance () are as follows: in E. coli-exposed hPBMCs, hsa-miR-485-5p and hsa-miR-4802-3p were downregulated (underlined blue); in B. pseudomallei-exposed hPBMCs, hsa-let-7d-5p, hsa-miR-1226-3p, and hsa-miR-23b-5p were upregulated (underlined green); in both B. pseudomallei- and F. tularensis-exposed hPBMCs, hsa-miR-30c-5p displayed upregulation (underlined gold).