Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis

Figure 7

Expression and prognostic value of TOP2A in HCC. (a–e) The expression data collected from 4 datasets from ONCOMINE indicated that TOP2A expression was upregulated in HCC tissues compared with the normal controls (all ). (f) Expression of TOP2A was increased in HCC cells based on the data from CCLE. (g) The Kaplan-Meier survival curves revealed that the high TOP2A expression predicted worse overall survival compared with the low TOP2A expression in HCC patients (log-rank ). (h) No significantly different survival times were found between patients with high TOP2A and patients with low TOP2A at tumor stage 1 (log-rank ). (i) High TOP2A expression predicted worse overall survival compared with the low TOP2A expression in HCC patients at tumor stage 2 (log-rank ). (j) High TOP2A expression predicted worse overall survival compared with the low TOP2A expression in patients with HCC at tumor stage 3 (log-rank ).

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