Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis

Table 2

Functional and pathway enrichment analyses of DEGs in HCC.

Term	Description	value	Count	Gene name
GO:0045926	Negative regulation of growth	9.99-07	7	MT1M, GPC3, MT1E, MT1H, MT1X, MT1G, MT1F
GO:0051301	Cell division	1.30-05	15	CDC6, CDK1, NUF2, TPX2, CENPF, NDC80, CDC20, UBE2C, CCNB1, CCNB2, MAD2L1, NCAPG, BUB1, CKS2, BUB1B
GO:0007067	Mitotic nuclear division	2.01-05	13	CDK1, CDC6, CCNB2, NUF2, BUB1, TPX2, CENPF, BUB1B, NDC80, ANLN, CDC20, PBK, ASPM
GO:0071276	Cellular response to cadmium ion	4.32-05	6	MT1E, CYP1A2, MT1H, MT1X, MT1G, MT1F
GO:0071294	Cellular response to zinc ion	8.05-05	6	MT1M, MT1E, MT1H, MT1X, MT1G, MT1F
GO:0007094	Mitotic spindle assembly checkpoint	6.21-03	5	MAD2L1, BUB1, CENPF, TTK, BUB1B
GO:0000922	Spindle pole	2.80-02	7	CCNB1, CDC6, MAD2L1, PRC1, TPX2, CENPF, CDC20
GO:0007062	Sister chromatid cohesion	3.61-02	7	MAD2L1, NUF2, BUB1, CENPF, BUB1B, NDC80, CDC20
KEGG:hsa04110	Cell cycle	4.15-03	9	CCNB1, CDK1, CDC6, MAD2L1, CCNB2, BUB1, TTK, BUB1B, CDC20
KEGG:hsa04978	Mineral absorption	2.54-02	5	MT1M, MT1E, MT1H, MT1X, MT1G, MT1F

DEGs: differentially expressed genes; GO: gene ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes. The bold genes are hub genes.