Research Article
Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma
Table 4
Pathway analysis of HNRNPAB-associated genes in Reactome database.
| | No. | Top 25 pathways in Reactome database | No. of input genes | value | -log ( value) | FDR |
| | 1 | Cell cycle | 31/682 | 5.59E-13 | 12.25258819 | 3.03E-10 | | 2 | Cell cycle, mitotic | 26/570 | 5.22-11 | 10.2823295 | 1.41-08 | | 3 | Metabolism of RNA | 26/782 | 3.66-08 | 7.436518915 | 5.05-06 | | 4 | Processing of capped intron-containing pre-mRNA | 15/256 | 3.74-08 | 7.427128398 | 5.05-06 | | 5 | mRNA splicing-major pathway | 12/185 | 3.20-07 | 6.494850022 | 3.46-05 | | 6 | mRNA splicing | 12/196 | 5.85-07 | 6.232844134 | 5.27-05 | | 7 | Gene and protein expression by JAK-STAT signaling after interleukin-12 stimulation | 8/74 | 7.94-07 | 6.100179498 | 6.11-05 | | 8 | Mitotic anaphase | 12/208 | 1.08-06 | 5.966576245 | 6.61-05 | | 9 | Mitotic metaphase and anaphase | 12/211 | 1.25-06 | 5.903089987 | 6.61-05 | | 10 | G2/M transition | 12/212 | 1.32-06 | 5.879426069 | 6.61-05 | | 11 | Mitotic G2-G2/M phases | 12/214 | 1.45-06 | 5.838631998 | 6.61-05 | | 12 | M phase | 16/390 | 1.47-06 | 5.832682665 | 6.61-05 | | 13 | Cooperation of prefolding and TRiC/CCT in actin and tubulin folding | 6/37 | 2.01-06 | 5.696803943 | 8.24-05 | | 14 | Interleukin-12 signaling | 8/85 | 2.20-06 | 5.657577319 | 8.36-05 | | 15 | APC/C-mediated degradation of cell cycle proteins | 8/90 | 3.34-06 | 5.476253533 | 1.09-04 | | 16 | Regulation of mitotic cell cycle | 8/90 | 3.34-06 | 5.476253533 | 1.09-04 | | 17 | Polo-like kinase-mediated events | 5/23 | 3.62-06 | 5.441291429 | 1.09-04 | | 18 | Separation of sister chromatids | 11/194 | 3.64-06 | 5.438898616 | 1.09-04 | | 19 | Cell cycle checkpoints | 13/279 | 3.91-06 | 5.407823243 | 1.09-04 | | 20 | Cleavage of growing transcript in the termination region | 7/67 | 4.93-06 | 5.307153081 | 1.23-04 | | 21 | RNA polymerase II transcription termination | 7/67 | 4.93-06 | 5.307153081 | 1.23-04 | | 22 | Interleukin-12 family signaling | 8/97 | 5.74-06 | 5.241088108 | 1.38-04 | | 23 | APC/C:Cdh1-mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 7/72 | 7.84-06 | 5.105683937 | 1.80-04 | | 24 | Chromosome maintenance | 8/105 | 1.01-05 | 4.995678626 | 2.14-04 | | 25 | APC/C:Cdc20-mediated degradation of mitotic proteins | 7/75 | 1.02-05 | 4.991399828 | 2.14-04 |
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