Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes

Table 1

Phenotype associated with the Arap3 gene in different organisms.

Organism	Gene	Function	Lethality	Lymphatic phenotype
Mouse	Arap3	Protein coding	Conditional Arap3 knockout lethal during gestation, impaired vascular development [10]	Lymphatic anomalies, dysregulation of Arap3 in a mouse model of lymphatic disease [6]
Zebrafish	arap3	Protein coding	/	arap3 fewer precursor lymphatic endothelial cells sprout from the cardinal vein [6]