Long Noncoding RNA HOTTIP Serves as an Independent Predictive Biomarker for the Prognosis of Patients with Clear Cell Renal Cell Carcinoma

Table 1

Main characteristics of the eligible studies.

Author	Year	Country	Ethnicity	Cancer type	Methods	Cut-off	Sample size	Survival analysis	Follow-up (total)	Covariants	NOS
Wang et al.	2015	China	Asian	PC	qRT-PCR	Fold-change	144	Multivariable analysis	60 Mons	LNM	7
Ge et al.	2015	China	Asian	HCC	qRT-PCR	NG	48	Kaplan–Meier curve	72 Mons	NG	7
Li et al.	2015	China	Asian	Osteosarcoma	qRT-PCR	Median	68	Multivariable analysis	60 Mons	Clinical stage, tumor size	7
Zhang et al.	2015	China	Asian	TSCC	qRT-PCR	Median	86	Multivariable analysis	60 Mons	LNM, clinical stage	7
Quagliata et al.	2014	Switzerland	Caucasian	HCC	qRT-PCR	ROC curve	52	Kaplan–Meier curve	80 Mons	NG	7
Ren et al.	2015	China	Asian	CRC	qRT-PCR	Median	156	Multivariable analysis	65 Mons	LNM, clinical stage	7
Lian et al.	2015	China	Asian	CRC	qRT-PCR	Fold-change	48	NG	NG	LNM, clinical stage, tumor size	7
Ye et al.	2016	China	Asian	GC	qRT-PCR	Median	98	Multivariable analysis	60 Mons	LNM, clinical stage, tumor size	7
Yang et al.	2016	China	Asian	BC	qRT-PCR	Median	100	Multivariable analysis	>100 Mons	LNM, clinical stage, tumor size	7
Sun et al.	2017	China	Asian	SCLC	qRT-PCR	NG	115	Kaplan–Meier curve	80 Mons	Clinical stage	7
Navarro et al.	2019	Spain	Caucasian	NSCLC	qRT-PCR		99	Multivariable analysis	98 Mons	NG	7
Zhao et al.	2018	China	Asian	GC	qRT-PCR	NG	126	Multivariable analysis	60 Mons	NG	7
Wu et al.	2018	China	Asian	HCC	qRT-PCR	ROC curve	155	Multivariable analysis	>100 Mons	Tumor recurrence	7
Zou et al.	2018	China	Asian	OC	qRT-PCR	Median	69	Kaplan–Meier curve	60 Mons	LNM	7
Lee et al.	2019	Korea	Asian	Prostate cancer	ISH	NG	70	Kaplan–Meier curve	>100 Mons	Pathologic stage	7
Balcin et al.	2018	Turkey	Caucasian	PRTs	qRT-PCR	Fold-change	100	Multivariable analysis	77 Mons	LNM	7
Peng et al.	2018	China	Asian	RCC	qRT-PCR	Median	60	NG	NG	Clinical stage, tumor size	7

PC: pancreatic cancer; HCC: hepatocellular carcinoma; TSCC: tongue squamous cell carcinoma; CRC: colorectal cancer; GC: gastric cancer; BC: breast cancer; SCLC: small cell lung cancer; NSCLC: non-small-cell lung cancer; PRTs: periampullary region tumors; OC: ovarian cancer; RCC: renal cell carcinoma; qRT-PCR: quantitative real-time polymerase chain reaction; ISH: in situ hybridization; LNM: lymph node metastasis; NG: not given.