Two Variants in the NOTCH4 and HLA-C Genes Contribute to Familial Clustering of Psoriasis

Table 2

Association of variants with psoriasis with a family history (PFH) in the multivariate regression model.

Variants	Frequency		PFH vs. control
	Freq_PFH^1	Freq_Control^2	OR (95% CI)	value
HLA-C alleles
HLA-C06:02	0.479	0.110	12.92 (11.41–14.64)
HLA-C07:04	0.015	0.010	3.19 (2.21–4.61)
NOTCH4
NOTCH4:G511S	0.092	0.018	2.15 (1.77–2.61)
HLA-B alleles
B-Y67C	0.082	0.087	1.80 (1.51–2.15)
HLA-DPB1 alleles
DPB1-F35L	0.407	0.437	1.38 (1.25–1.52)
TAP2
TAP201:03	0.028	0.025	0.41 (0.29–.59)

¹Freq_PFH: the allele frequency in patients with PFH. ²Freq_Control: the allele frequency in healthy controls.