A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population

Table 4

The overrepresentation pathways identified by the top 287 genes with a value in this pooling GWAS.

Pathway name	Total	Observed	-ratio		Adj-
JAK-STAT signaling pathway	155	6	6.27	0.0004	0.0054
Neuroactive ligand-receptor interaction	256	8	5.06	0.0002	0.0054
Pathways in cancer	330	8	3.93	0.0011	0.0099

The number of reference genes in the category (total); ratio of enrichment (-ratio); value from hypergeometric test; value adjusted by the multiple test adjustment (Adj-), the significant threshold of Adj- is .