The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation

<div>CDK1 overexpression attenuated miR-193b-3p-modulated actions on the HCC cell proliferation and migration. (a) Relative expression of miR-193b-3p in LO2, SMMC7721, and HCC-LM3. (b) SMMC7721 cells were transfected with pcDNA3.1 or pcDNA3.1-CDK1. (c)–(f) SMMC7721 cells were co-transfected with miRNAs and plasmids, and at 24 hours after co-transfection, (c) cell viability of SMMC7721 cells; (d) cell proliferation of SMMC7721 cells; (e) cell apoptosis of SMMC7721 cells as determined by TUNEL assay; (f) the caspase-3/-7 activities of SMMC7721 cells; and (g) cell migration of SMMC7721 cells. <span class="nowrap"><svg height="8.8423pt" id="M19" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 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International Journal of Genomics

fig11

Figure 11

Figure 11: The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation 

Figure 11 | The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation 