Correlation between LSM1 Expression and Clinical Outcomes in Glioblastoma and Functional Mechanisms

Figure 4

Effects of LSM1 modulation on U87 GBM cell behavior. Cellular consequences of LSM1 modulation in U87 GBM cells were evaluated. (a) Western blot analysis confirms the efficiency of LSM1 knockdown and overexpression, using scrambled-siRNA and vector controls, respectively. (b) Semiquantification of the western blot results demonstrates successful LSM1 knockdown and overexpression. (c) The impact on cell proliferation is evaluated using the CCK-8 assay, revealing that LSM1 overexpression promotes cell proliferation, while knockdown of LSM1 inhibits cell growth in U87 GBM cells. (d) Cell invasion capacity is assessed, indicating that LSM1 overexpression enhances GBM cell invasion, while LSM1 knockdown significantly inhibits this process. These findings elucidate the functional implications of LSM1 in GBM, where overexpression promotes cell proliferation and invasion, while knockdown exerts suppressive effects. LSM1 emerges as a potential therapeutic target for GBM. indicates by the Student’s -test between the two groups.

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