A Five-LLPS Gene Risk Score Prognostic Signature Predicts Survival in Hepatocellular Carcinoma

Figure 1

The process of constructing the five-LLPS gene risk score signature. First, 43 differentially expressed LLPS genes associated with OS in HCC patients were identified by differential expression analysis and univariate Cox proportional hazards regression analysis. Next, Least Absolute Shrinkage and Selection Operator (LASSO) Cox penalized regression analysis was applied to construct a gene risk score signature for prognosis prediction. Then, the gene risk score signature was generated based on five LLPS genes (BMX, FYN, KPNA2, PFKFB4, and SPP1). Finally, the five-LLPS gene risk score signature was validated by the validation dataset and clinical samples using experiments.