Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review

Table 2

Candidate genes and genomic regions for FY and FP in Holstein and its crossbreds.

SNP name	Gene	Chromosome	Trait	Breed	Number of cattle	Authors
rs29020642	LOC512171	1	FY	Canadian Holstein	462	[25]
rs41634488	LOC786403	1
rs41637121	APP	1
rs41588659	COL1A2	4
rs41591894	ITPR2	5
rs41592942	GUCY2C	5
rs41652648	ITPR2	5
rs41653025	LOC540856	10
rs43703342	LOC514626	11
rs41645253	MGC139244	24
rs41569649	CAMK2G	28
rs41653440	PSAP	28	FY
rs41653491	LOC514949	28
rs43709929	LOC514870	3
rs29018853	LEC3	6
rs41592660	LOC616136	9
rs41657163	LOC535127	9
rs43710950	TPM1	10
rs41567322	TG	14
rs41579063	BIG1	14
rs41639879	LOC505156	17
rs41641678	LOC514186	21
rs41643783	MGC139789	21
rs41648176	LOC515764	26
rs29017368	LOC515967	5	FY	Chinese Holstein	2,093	[21]
rs41648982	LOC511240	5
rs110090404	C14H8orf33	14
rs41664719	LOC516454	X
rs109948273	EIF2C2	1	FP
rs41617243	KBTBD10	2
rs41652649	ITPR2	5
rs43499009	NFIB	8
rs110704765	LOC526069	11
rs110710474	GFI1B	11
rs109436130	KHDRBS3	14
rs109529219	RHPN1	14
rs110143087	KCNK9	14
rs110293317	KHDRBS3	14
rs110323635	MAPK15	14
rs110411273	GPR20	14
rs110718625	KHDRBS3	14
rs111022074	LOC100138440	14
rs41567288	NIBP	14
rs41576704	EIF2C2	14
rs108995214	KHDRBS3	14
rs109118650	LOC618755	14
rs109225594	KCNK9	14
rs109230014	KCNK9	14
rs109241573	KHDRBS3	14
rs109402117	LOC618755	14
rs109476486	LYPD2	14
rs109617015	ZC3H3	14
rs109661298	EEF1D	14
rs109670279	PTK2	14
rs109742607	MAPK15	14
rs110057993	KHDRBS3	14
rs110165168	MIRN30D	14
rs110339989	OPLAH	14
rs110351374	COL22A1	14
rs110351748	COL22A1	14
rs110424520	GPR20	14
rs110501942	LOC618755	14
rs110502094	LOC100138440	14
rs110522477	KHDRBS3	14
rs110545496	KHDRBS3	14
rs110626984	CYP11B1	14
rs110775004	NIBP	14
rs110892754	LOC524939	14
rs111018678	NIBP	14
rs41576704	EIF2C2	14
rs41624797	PTK2	14
rs41627764	ZNF623	14
rs41630614	LOC785799	14
rs41657812	LOC100138440	14
rs42305942	LOC100138440	14
rs42310935	LOC100138440	14
rs55617160	NIBP	14
rs109950724	LOC782348	5	FY	U.S. Holstein	1,654	[19]
rs110355546	ZBPI	13
rs41639184	LPP	X
rs110267314	LM03	5	FP
rs41592948	GABARAPL1	5
rs109146371	FOXHI	14
rs109350371	LOC786966	14
rs109421300	DGAT1	14
rs109558046	VPS28	14
rs109752439	ZAT34	14
rs110017379	NIBP	14
rs110060785	GPITIBP1	14
rs110891564	KCNK9	14
rs110091513	SART3	17
rs109062793	AP1B4	X
rs109116007	SYTL5	X
rs41919985	FASN	19	FY	Italian Holstein	800	[22]
rs41613079	EPHA7	9	FP	Russian Holstein	61	[20]
rs42723319	EPHA7	9
rs109350371	LOC786966	14
rs109421300	DGAT1	14
rs134390757	LxR-α	15	FY	Italian Holstein	45,115	[23]
rs135588030	ORL2	5	FP
rs43349286	LPAAT	23
rs41624917	PLCE1	26
rs41670205	LRP1B	2	FP	Colombian Holstein	150	[10]
rs109245784	CLCN1	4
rs43655765	SNRNP200	11
rs110897514	PCDH18	17
rs41571534	WSCD1	19
rs41629750	GRINA	14	FP	Russian Crossbreds	477	[9]
rs109350371	PLEC	14
rs109421300	DGAT1	14
rs109968515	CYHR1	14
rs110199901	ZNF696	14
rs17870736	VPS28	14
rs42406616	ABCC9	5	FY	US Holstein	294,079	[26]
rs42718234	ABCC9	5
rs109350371	LOC786966	14
rs133114040	EPS8	5	FP
rs109146371	FOXH1	14	FP	Chinese Holstein	295	[11]
rs109752439	C14H8orf33	14
rs208148726	AKT3	16
rs43526055	ADRA1B	7	FY	Chinese Holstein	1220	[14]
rsl37676276	VIT	11
rs135780687	GRPR	x
rsl09528658	EF400	17
rs42295213	EPHA6	1	FP
rs136949224	SCARA5	8
rs110825388	CPSF1/ADCK5	14	FY	French Holstein	6321	[13]
rs211210569	MGST1	5
rs208248675	MGST1	5	FP
rs136548039	HERC5	6
rs109982707	PAEP	11
rs109234250	DGAT1	14
rs208675276	GPAT4 5 UTR	27
rs110199901	LY6H	14	FY	Chinese Holstein	300	[15]
rs109742607	MAPK15	14	FP
rs41624797	PTK2	14
Na rs	LY6H	14
rs109476486	LYNX1	14
rs109617015	VAMP2	14
rs110339989	OPLAH	14
rs137787931	MROH1	14
rs17870736	VPS28	14
rs41627764	MIR193A-2	14
rs41630614	RPL8	14
rs41596885	PDE4B	3	FY	Korean Holstein	2780	[17]
rs42314807	PDE4B	3
rs43454033	ANO2	5
rs109234250	DGAT1	14
rs109326954	DGAT1	14
rs109421300	DGAT1	14
rs110812136	SPATC1	14
rs135258919	HSF1	14
rs208317364	DGAT1	14
rs435871639	PKHD1	23
rs109414214	EXT1	14	FP	Indian Crossbreds	96	[27]
rs109632163	NOV	14
rs41614632	-	14
rs41665025	SNTG1	14
rs41730911	FABP, PMP2	14
rs42485761	ZFPM2	14
rs43067787	KCNB2	14
rs108957364	AARD	14
rs110390518	-	14
rs110981268	SNX16	14
rs81118743	RF00026	14
rs43527533	TENM2	7	FY	Chinese Holstein	999	[7]
rs42206791	METTL15	15
rs137260850	PLA2G4A	16
rs109656599	CDH13	18
rs109595510	RCSD1	3	FP
rs210744919	MGST1	5
rs133840542	SUPT2OH	12
rs137071126	SLC52A2	14
rs109278135	NOL4	24
rs133996308	PLAU	28