Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review

Table 3

Candidate genes and genomic regions for PY and PP in Holstein and its crossbreds.

SNP name	Gene	Chromosome	Trait	Breed	Number of cattle	Authors
rs41591535	LOC781748	4	PY	Canadian Holstein	462	[25]
rs29011990	MGC155155	8
rs41636749	LOC538513	18
rs41648723	CTBP2	26
rs41606880	JDP1	28
rs41650658	NRCAM	4	PP
rs29014633	CACNG2	5
rs41590827	RAC2	5
rs41593881	HIF1A	10
rs29021058	PLCG1	13
rs41566192	MGC127374	13
rs41637636	SLC38A3	22
rs29016156	LOC517805	23
rs109452554	ETS2	1	PY	Chinese Holstein	2,093	[21]
rs109680710	DIP2A	1
rs41586699	PDE9A	1
rs109271556	LOC781902	3
rs109700191	SLC30A7	3
rs29025951	LOC100138725	3
rs41589462	LOC539739	3
rs110896997	PDHA2	6
rs41659807	LOC788115	9
rs109819417	NKAIN3	14
rs110618422	CSF2RB	5	PP
rs42552739	NCF4	5
rs81154068	HERC3	6
rs29018333	LOC536367	6
rs41622323	PKD2	6
rs43463988	LOC100140991	6
rs110805364	NIBP	14
Na rs	GHR	20
rs109181046	GDNF	20
rs110679619	RICTOR	20
rs29013890	LOC782833	20
rs29014437	LOC782284	20
rs29018751	NIPBL	20
rs41574319	RAI14	20
rs41581059	LOC100138964	20
rs41937533	LOC518808	20
rs41941633	FYB	20
rs41941646	C9	20
rs41942492	NIPBL	20
rs41945918	LOC782462	20
rs42954630	NIPBL	20
rs109583255	CRABP1	21	PY	U.S. Holstein	1,654	[19]
rs29011 699	ALDH5A1	23
rs110736402	L424P2	X
rs41598282	ATP1B4	X
rs110675489	SREBF2	5	PP
rs110931400	PDGFRA	6
rs111032162	PDGFRA	6
rs109024105	RPL37	9
rs109352200	USP 3 8	17
rs41256775	L0052 8054	17
rs109375227	Artora	18
rs109570377	CX036	X
rs108964624	LOC781178	X
rs110304690	COL4	X
rs110328561	LOC781178	X
rs41628209	LOC616260	X
rs42967999	LOC781902	3
rs41569048	PTHLH	5	PP	Dutch Holstein	1,713	[28]
rs41640170	HEATR7B2	20
rs42529901	LOC788223	6	PY	Portuguese Holstein	526	[24]
rs42749054	MAPK9	7
rs109593545	BRD7	18
rs41255191	OTUD7A	21
rs109826203	ACSM5	25
Na rs	CSN3	6	PP	Italian Holstein	800	[22]
rs109163366	PPARGC1A	6
rs110980619	HPS3	1	PY	Russian Holstein	61	[20]
rs41647284	SLC16A7	5
rs41601570	ARL15	20	PP
rs109007595	POU1F2	1	PP	Italian Holstein	45,115	[23]
No rs	PPARGC1A	6
rs109579682	PPARGC1A	6
rs43703011	CSN3	6
rs43703017	CSN5	6
rs137457402	LPIN1	11
rs41255713	CCL3	19
rs109136815	GHR	20
rs29023352	INSIG1	4	PP	Colombian Holstein	150	[10]
rs41624303	Arntl2	5
rs29014693	NMBR	9
rs41772701	CAPN5	15
rs110425841	PODXL2	22
rs41576177	OSBPL1A	24
rs109670279	BOD1L1	6	PP	Russian Crossbreds	477	[9]
rs43592374	UBE3D	9
rs43710185	IL15	17
rs109774038	NDUFA9	5	PY	US Holstein	294,079	[26]
rs132896414	GALNT8	5
rs379188781	CCND2	5
rs135228504	ZNF34	14
rs109558046	VPS13B	14	PP
rs110478571	NLK	19	PP	Chinese Holstein	769	[12]
rs109558046	LOC104975266	20
rs110000229	GHR	20
rs41257416	HCN1	20
rs42418694	SND1	4	PY	Chinese Holstein	295	[11]
rs41579063	ARFGEF1	14
rs41629750	SPATC1	1	PP
rs109748124	TNFSF10	1
rs41602511	YTHDF3	1
rs41617243	KLHL41	2
rs110256520	ATP1A1	3
rs110420888	ATP1A1	3
rs134541510	RPAP3	5
rs137408198	CD27	5
rs29015155	RPAP3	5
rs41592948	GABARAPL1	5
rs110672723	CSN2	6
rs110727998	GML	14
rs41579932	ARMC1	14
rs110834172	KSR2	17
rs29014438	SLC1A3	20
rs29021190	SLC1A3	20
rs41639260	GHR	20
rs41934711	CCNB1	20
rs134480235	SLCO1A2	5	PY	Chinese Holstein	1220	[14]
rs109875012	ZNF384	5	PP
rs108996837	EXOC3L4	21
rs136903701	ABCC9	5	PY	French Holstein	6321	[13]
rs43703011	CSN2	6
rs134511693	EFNA4	3	PP
rs456403270	TBC1D22A	5
rs383909572	HSTN	6
rs41622323	PKD2	6
rs135458711	SLC39A4	14
rs110144962	APOA4	15
rs208817293	WDR74/U2	29
rs378017490	PICALM	29
rs799074643	UMPS	1	PY	Korean Holstein	2780	[17]
rs211419403	GFRA2	8
rs109957491	MFSD1	1	PY	Chinese Holstein	999	[7]
rs109097262	PLCB4	13
rs41906111	MY01D	19
rs43496186	WNT9A	7	PP
rs109425744	CORO2B	10
rs135708753	ATP11A	12
rs132711282	FBX O 43	14
rs43002440	KHDRBS3	14
rs110387086	MLXIP	17