Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review

Table 4

Candidate genes and genomic regions affecting multiple milk production traits in Holstein and its crossbreds.

SNP name	Gene	Chromosome	Traits	Breed	Authors
rs41629125	ITGB5	1	MY, FY, and PY	Canadian Holstein	[25]
rs41631818	MGC128242	1	MY, FY, and PY
rs41587408	PDZK1	3	FP and PP
rs41578761	LOC529633	7	FY and PY
rs41662488	LOC785678	9	MY and PY
rs41569023	ROCK2	11	MY nad PY
rs41579049	5-OPase	14	FY and FP
rs41580517	KCNQ3	14	FY and FP
rs41587081	ZFHX4	14	MY and FP
rs41628862	BIG1	14	MY and PY
rs41633631	TG	14	MY and FP
rs41570561	SCARB1	17	FP and PP
rs41581694	FOXA3	18	MY and PY
rs41585246	SERPINA3-5	21	MY and PY
rs41644615	SERPINA5	21	MY, FY, and PY
rs41640789	POLR1C	23	FY and FP
rs41643632	LOC534225	23	MY and PY
rs43282015	LOC614166	1	MY and PY	Chinese Holstein	[21]
rs41663626	LOC534011	3	MY and PY
No rs	HAL	5	MY and PY
rs110727998	GML	14	MY and FP
No rs	COL22A1	14	MY and PY
rs109146371	FOXH1	14	MY, FY, and PP
rs109350371	LOC786966	14	MY, FY, PY, and PP
rs109421300	DGAT1	14	MY, FY, and PP
rs109752439	C14H8orf33	14	MY and PY
rs109968515	CYHR1	14	MY, FY, and PP
rs110017379	NIBP	14	MY, PY, and FP
rs110060785	GPIHBP1	14	MY, PY, and FP
rs110199901	ZNF66	14	MY and FP
rs110622450	COL22A1	14	MY and FP
rs17870736	VPS28	14	MY, FY, and PP
rs41256919	MAF1	14	MY and FP
rs41629750	GRINA	14	MY, FP, and PP
rs41583200	C26H10orf84	26	MY and PY
rs42462826	FKBP2	1	FY and PY	U.S. Holstein	[19]
rs109250591	ITC14	1	FY and PY
rs109703572		9	MY and FY
rs43101493	GNAS	13	MY, FY, and PY
rs41585412	GNAS	13	MY, FY, and PY
rs41630667	GNAS	13	MY, FY, and PY
rs111018678	NIBP	14	FP and PP
rs42422883	HHIP	17	FY and PY
rs108993234	PGLYRPI	18	MY, FY, and PY
rs29010796	MAF	18	FY and PY
rs109343058	GPRI 10	23	FY and PY
rs110886345		26	FY, PY, and PP
rs110898125		26	FP and PP
rs41626960	MGMT	26	FY and PY
rs42227052	FUT10	27	MY, FY, and PY
rs41575183		27	FY and PY
rs109335394		X	FY and PY
rs41579345	GLRA2	X	FY and PY
rs41628209	LOC616260	X	FY and PY
rs41255709	CXCR1	2	MY, FY, and PY	Italian Holstein	[22]
rs29004485	LEP	4	MY, FY, and PY
rs29004488	LEP	4	MY, FY, and PY
rs109299401	CSN3	6	PY and PP
rs133669403	PPARGC1A	6	MY and PY
rs43703011	CSN2	6	MY and PY
rs109625649	LGB	11	MY and PY
rs110066229	LGB	11	MY and PY
rs41255679	LGB	11	MY and PY
No rs	CRH	14	PY and PP
rs109162116	DGAT1	14	MY, FY, PY, and FP
rs109234250	DGAT1	14	MY, FY, PY, FP, and PP
rs41580467	TG	14	MY and FP
rs41758918	TPH1	15	MY and PY
rs42321611	PRLR	20	MY, FY, PY, and PP
rs42714482	THRSP	29	MY, FY, and PY
rs29017970	LOC104973750	13	MY and PY	Russian Holstein	[20]
rs41850250	TRAFD1	17	MY and PY
rs135514413	ETS2	1	FP and PP	Italian Holstein	[23]
rs41608610	DGKG	1	MY, FP, and PP
rs109299401	CSN2	6	PY and PP
rs110981354	CSN1S1	6	FY, FP, and PP
rs133669403	PPARGC1A	6	MY, FP, and PP
rs43703013	CSN4	6	MY and PP
rs43703015	CSN4	6	MY, FY, and PY
rs43706475	CSN3	6	MY and PY
rs110590698	LPL	8	FY, FP, and PP
rs8193666	TLR4	8	MY, FP, and PP
rs110757796	FABP4	14	MY and PY
rs110937773	FGF2	17	MY and FY
rs109578101	STAT5A	19	MY, PY, and FP
rs109686238	CCL3	19	FY and PY
rs109428015	PRLR	20	FP and PP
rs41923484	GHR	20	PY, FP, and PP
rs41257077	PI	21	FY and PY
rs43765462	LTF	22	FY and FP
rs43706495	BTN1A1	23	MY and FP
rs109913786	AGPAT6	27	FY and FP
rs381714237	FCGR2B	3	MY, PY, and PP	US Holstein	[26]
rs110825637	MGST1	5	FY and FP	Chinese Holstein	[12]
rs137735153	PLEKHA5	5	FY and FP
rs109901151	SLC4A4	6	MY and PY
rs110694875	ADAMTS3	6	MY and PY
rs136639319	TBC1D1	6	FP and PP
rs137147462	GC	6	MY and PY
rs378415122	CENPE	6	MY, FY, and PY
rs385060942	CENPE	6	MY, FY, and PY
rs453960300	CENPE	6	MY, FY, and PY
ss2137349051	CENPE	6	MY, FY, and PY
ss2137349053	CENPE	6	MY, FY, and PY
rs377943075	ACSBG2	7	FY and PP
rs134985825	RETSAT	11	MY, FY, PY, and PP
rs109146371	PPP1R16A	14	MY, FY, PY, and PP
rs109350371	PLEC	14	MY, FY, PY, and PP
rs109558046	ARC-ADGRB1	14	MY, FY, PY, and FP
rs110914335	LY6H (d)	14	MY and PY
rs134444531	NLK	19	PY and PP
rs41573457	MRPS30	20	MY and PP
ss2137349058	MAP3K1	20	MY, FY, and PY
rs41589462	KCND3	3	FP and PP	Chinese Holstein	[11]
rs136195618	PROP1	7	MY and PY
rs109350371	PLEC	14	MY, PY, FP, and PP
rs109421300	DGAT1	14	MY, FP, and PP
rs109968515	CYHR1	14	FY and PY
rs110017379	TRAPPC9	14	MY, FP, and PP
rs41579243	FAM135B	14	FP and PP
rs109646517	MTMR3	17	MY and PY
rs29014437	SLC1A3	20	MY and PP
rs41580312	OSMR	20	MY and PP
rs41942492	NIPBL	20	FP and PP
rs42340412	ARID5B	28	FP and PP
rs109421300	DGAT1	14	FP and PP	Chinese Holstein	[14]
rs109007040	VPS13B	14	MY, FP, and PP	French Holstein	[13]
rs109421300	DGAT1	14	MY and PY
rs41921161	CCDC57	19	FY and FP
rs110231369	ARHGEF28	20	FY and PY
rs385640152	GHR	20	FP and PP
No rs	ADCK5	14	MY, FY, FP, and PP	Chinese Holstein	[15]
No rs	FOXH1	14	MY, FY, FP, and PP
No rs	GRINA	14	FY, FP, and PP
No rs	SLC52A2	14	MY, FY, FP, and PP
rs109146371	FOXH1	14	MY, FY, FP, and PP
rs109752439	C14H8orf33	14	FY and FP
rs110323635	MAPK15	14	FY and FP
rs721532493	PALLD	8	MY, FY, and PY	Korean Holsteins	[17]
rs109421300	DGAT1	14	MY, FY, PY, and PP
rs135549651	SMPD5	14	MY, FY, PY, and PP
rs207655744	HSF1	14	MY and FY
rs208640292	HSF1	14	MY and FY
rs209876151	DGAT1	14	MY and FY
rs211016627	HSF1	14	MY and FY
rs211223469	DGAT1	14	MY and FY
rs211282745	HSF1	14	MY and FY
rs384957047	DGAT1	14	MY and FY
rs380223715	PKHD1	23	MY and PY