Research Article

Stratifin Promotes Hepatocellular Carcinoma Progression by Modulating the Wnt/β-Catenin Pathway

Figure 1

SFN gene expression is upregulated in HCC cells and tissues. (a) SFN mRNA expression in 377 HCC samples compared with 50 nontumor samples was analyzed in the TCGA database. (b, c, d, and e) SFN mRNA expression in HCC tissues in four Oncomine datasets (Roessler liver, Mas liver, Roessler liver 2, Wurmbach liver). (f) SFN mRNA expression was measured in five kinds of HCC cell lines and normal liver cells (L02) by RT‒qPCR in three independent experiments. (g) SFN mRNA expression was measured in 34 paired fresh HCC tissues and adjacent nontumor tissues by RT‒qPCR. (h) SFN protein expression was measured in five HCC cell lines and in normal liver cells (L02) by WB in three independent experiments. (i) Representative WB images from 34 paired fresh HCC tissues and adjacent nontumor tissues. (j) SFN protein expression in HCC tissues and nontumor tissues in the Human Protein Atlas. **P < 0.01, ***P < 0.001, ****P < 0.0001.
(a)
(b)
(c)
(d)
(e)
(f)
(g)
(h)
(i)
(j)