Recovery of the Cell Cycle Inhibition in CCl_𝟒-Induced Cirrhosis by the Adenosine Derivative IFC-305

Table 1

Effect of IFC305 on mitochondrial parameters in cirrhotic livers.

Treatment	(ATP); μmol/gwt	State 3; Glutamate	RC; Glutamate	ΔΨ; ΔDO 540 nm
Controls	3.0 ± 0.7	42 ± 4	5.4 ± 0.5	191 ± 4
Cirrhosis	2.0 ± 0.16*	34 ± 3	2.8 ± 0.4*	164 ± 8*
Plus saline
After 5 wks	2.2 ± 0.06	29 ± 3*	3.6 ± 0.3*	168 ± 10*
After 10 wks	2.8 ± 0.13	47 ± 6	4.3 ± 0.4	180 ± 6
Plus IFC305
After 5 wks	2.9 ± 0.3**	38 ± 5	5.2 ± 0.6**	197 ± 12**
After 10 wks	3.7 ± 0.01**	48 ± 6	6.2 ± 0.5**	200 ± 4**

The results are expressed as mean ± SE of seven individual determinations. State 3 is expressed as natoms O₂/min/mg of protein for glutamate-malate (site I) in the presence of ADP. RC: respiratory control (state 3/state 4). Statistics: ^*𝑃≤0.01 versus the control group; ^**𝑃≤0.01 versus the cirrhotic plus saline group. ATP concentration and ΔΨ were determined as described in Section 2. gwt: gram of wet tissue.