Recovery of the Cell Cycle Inhibition in CCl_𝟒-Induced Cirrhosis by the Adenosine Derivative IFC-305

Table 2

Summary of the effects of IFC305 treatment on protein expression in CCl₄-induced cirrhosis.

Protein	Cirrhosis T0	Cirrhosis progress		IFC305 treatment
		SS5 weeks	SS10 weeks	IFC5 weeks	IFC10 weeks
PCNA	NC	↓	↓ ↓	↑↑↑	↑↑↑
Cyclin D1	NC	↑	↑	↑↑	↑
Cyclins E, A	NC	NC	NC	NC	NC
Cyclin B1	NC	NC	↓	↓	↓
CDK4	NC	NC	↑↑↑	↑↑↑	↑↑↑
CDK6	↑↑↑	NC	NC	↑↑↑	↑↑↑
p21	↓ ↓	↓ ↓	NC	NC	↓
p27	NC	NC	↑	NC	NC
pRb (Ser 795)	↓	NC	NC	↑	↑
E2F1	↓ ↓	↓	NC	↑	NC
DP1	NC	NC	NC	NC	NC
p53	NC	↑	NC	↑↑	↑↑
MDM2	NC	↓	NC	↓	NC
Serum HGF	↑	↑	↑	↑↑	↑↑
Liver HGF	NC	NC	NC	NC	NC
cMet	NC	↑	NC	↑	NC

Each group was compared to the control group. NC: no changes. ↑ or ↓: less than 50% of increase or decrease with respect to the control. ↑↑ or ↓ ↓: 50 to 100% of increase or decrease. ↑↑↑: more than 100% of increase.