Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis

Table 6

Cutoffs of measures and estimates for detection of early renal impairment with their measures of diagnostic accuracy.

	Cutoff of early RI	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Cr	0.75 mg/dL	68.8	54.5	76.7	44.4
CCr	77 mL/min	77.3	64.6	54.5	60.9
CysC	1.2 mg/L	89.6	63.6	84.3	73.7
MDRD 4	96.8 mL/min	72.7	54.2	57.3	62.7
MDRD 6	85.5 mL/min	72.7	60.4	54.6	59.2
C-G formula	119.3 mL/min	54.5	58.3	48.3	47.8
CKD-EPI-Cr	99.8 mL/min	77.3	55.2	63.3	70.9
CKD-EPI-CysC	38.7 mL/min	72.7	66.7	68.6	71.0
CKD-EPI-Cr-CysC	52.8 mL/min	77.3	61.4	66.7	73.0

C-G formula, Cockcroft-Gault formula; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; Cr, creatinine; CCr, creatinine clearance; CysC, cystatin C; MDRD, modification of diet in renal disease equation with 4 and 6 variables; NPV, negative predictive value; PPV, positive predictive value; RI, renal impairment.