Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control

<div>Time course of the effects of boldine on the alanine gluconeogenesis in the perfused livers isolated from fasted rats. Livers were perfused as described in the Materials and Methods. Boxes near to the time scale indicate the alanine and boldine infusion periods and concentrations. The outflowing perfusate was sampled every 2 minutes and used to quantify glucose, pyruvate, lactate, ammonia, and urea. Oxygen uptake was monitored polarographically by a platinum electrode. 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5 liver perfusion experiments.</div>

International Journal of Hepatology

fig5

Figure 5

Figure 5: Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control 