Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis

Table 1

Demographic and laboratory characteristics.

Characteristic	Patients without pruritus; ()	Patients with pruritus; ()	value or mean difference; (95% CI)
Gender—females (%)	65 (48)	41 (41)	0.33
Age in years ()			0.45 (-3.85–1.72)
Diagnosis—number (%)
Pancreatic carcinoma	100 (73)	60 (61)	0.06
Cholangiocarcinoma	28 (21)	26 (26)
Papillary carcinoma	8 (6)	13 (13)
Hb—mmol/L ()			0.22 (-0.10–0.44)
Leucocytes—10^9/L ()			0.31 (-1.48–0.47)
Thrombocytes—10^9/L ()			0.13 (-6.31–48.0)
AST—U/L median (IQR)	162 (100–247)	114 (67–199)	<0.01
ALT—U/L median (IQR)	260 (129–407)	197 (78–320)	<0.01
LD—U/L median (IQR)	237 (201–284)	239 (203–274)	0.93
INR median (IQR)	1.1 (1.00–1.30)	1.0 (0.975–1.10)	<0.01
Albumin—g/L ()			0.99 (-2.21–2.17)
MELD-score ()			0.47 (-1.37–2.93)
Creatinine—μmol/L ()			0.98 (-11.6–11.2)
eGFR (MDRD) —ml/min ()			0.32 (-14.7–4.83)

Abbreviations: Hb: hemoglobin; AST: aspartate aminotransferase; ALT: alanine aminotransferase; LD: lactate dehydrogenase; INR: international normalized ratio; MELD: model for end-stage liver disease; eGFR: estimated glomerular filtration rate; MDRD: modification of diet in renal disease.