|
| Authors | Year | Populations | Subjects | Associations with the polymorphism |
|
| Large et al. [40] | 1997 | Swedish | 140 Caucasian women with a wide range of obesity | Obesity |
| The Quebec Family Study [41] | 2000 | Canada | Caucasian men and women | Obesity, hyperlipidemia |
| Hayakawa et al. [42] | 2000 | Japanese | 210 Japanese men from a population | No association with obesity |
| Jia et al. [43] | 2000 | USA | Caucasians (298 hypertensive versus 298 normotensive subjects) | No association with hypertension |
| Xie et al. [44] | 2000 | USA | Black and white Americans (including normotensive and hypertensive subjects) | No associations with hypertension |
| Candy et al. [45] | 2000 | English | England Black African men (including 192 hypertensive and 123 normotensive men) | No association with hypertension |
| Cockcroft et al. [46] | 2000 | Caucasian | 127 young normotensive men | Forearm vascular responses (hypertension) |
| Meirhaeghe et al. [47] | 2000 | French | 1195 middle-aged Caucasian from the urban population | Obesity, if subjects carry Gln27Gln |
| | | | |
| Kato et al. [48] | 2001 | Japanese | 842 hypertensive and 633 normotensive subjects | BP levels (hypertension) in normotensives |
| Bengtsson et al. [49] | 2001 | Swedish | Hypertensive patients with and without type 2 DM | Hypertension in subjects with DM |
| The Bogalusa Heart Study [50] | 2002 | USA | 1151 Caucasian and Black Africans children (including boys and girls) | Weight gain in males |
| Kim et al. [51] | 2002 | Korean | type 2 DM patients | Obesity, DM, hyperlipidemia |
| Chang et al. [52] | 2002 | Taiwanese | type 2 DM patients | Type 2 DM |
| Van Rossum et al. [53] | 2002 | Dutch | 286 subjects with a significant weight gain over 7 years including men and women | Weight gain in men, but not in women |
| The HERITAGE family study [54] | 2003 | Canada | Sedentary black and white women | Lower fat in obese white women |
| Pereira et al. [20] | 2003 | Brazilian | 1576 ethnically mixed population (including men and women) | Systolic BP, BMI |
| The Olivetti heart study [55] | 2004 | Italian | 993 middle-aged men regardless of BP levels or BMI | No association with obesity or hypertension |
| Ikarashi et al. [56] | 2004 | Japanese | type 2 diabetic patients | Association with IR |
| Tafel et al. [57] | 2004 | Germany | extremely obese children | No association with obesity |
| Ellsworth et al. [58] | 2005 | USA | Black and white American men and women | BMI (obesity) in only men |
| Trombetta et al. [59] | 2005 | Brazilian | Brazilian healthy women | Hypertension (blunted forearm vasodilation response) |
| Masuo et al. [21] | 2005 | Japanese | Nonobese, normotensive men | Weight gain, BP elevation, obesity-HT |
| Masuo et al. [60] | 2005 | Japanese | Nonobese, normotensive men | Insulin resistance |
| Masuo et al. [61, 62] | 2006 | Japanese | Normotensive men (including nonobese and obese men) | Weight gain, blunted leptin-sympathetic axis |
| Kurabayashi et al. [63] | 2006 | Japanese | PCOS patients | Association with high prevalence of PCOS Accompanying IR |
| Gjesing et al. [64] | 2007 | Dutch | 7808 white subjects | No association with hypertension or obesity |
| Masuo et al. [65] | 2007 | Japanese | 219 nonobese, normotensive men | Association with high SNA followed by IR |
|
