Oxidative Stress in Hypertensive Patients Induces an Increased Contractility in Vein Grafts Independent of Endothelial Function

Figure 1

Cumulative dose-response curves (CDRC) to agonists in SV rings. (a) CDRC to Angiotensin II (Ang II) in HT (black) and NT (white) patients in the absence (squares) or presence (circles) of DPI. ***𝑃<0.001 HT versus NT. 𝑓𝑓: 𝑃<0.03 HT versus HT+DPI; 𝑓𝑓𝑓: 𝑃<0.001 HT versus HT+DPI. ⁺⁺⁺𝑃<0.001 HT versus NT+DPI. (b) CDRC to norepinephrine (NE) in HT (black) and NT (white) patients in the absence (squares) or presence (circles) of DPI. ***𝑃<0.001 HT versus NT. 𝑓𝑓: 𝑃<0.03 HT versus HT plus DPI; 𝑓𝑓𝑓: 𝑃<0.001 HT versus HT plus DPI. ⁺⁺⁺𝑃<0.001 HT versus NT plus DPI. Data are expressed as mean ± standard error. The number of rings is given in parentheses.

(a)

(b)