Research Article
Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats
Table 1
Resting MAP recorded on separate days before drug treatments, as indicated.
| | Treatment | MAP (mmHg) |
| | Group 1 () | | | Saline | 132 ± 14 | | Ang-(1-7) (15 pmol/kg/min) | 124 ± 4 | | Candesartan (0.01 mg/kg) | 131 ± 6 | | Ang-(1-7) and candesartan | 134 ± 4 |
| | Group 2 () | | | Saline | 131 ± 13 | | Ang-(1-7) (15 pmol/kg/min) | 136 ± 13 | | Candesartan (0.01 mg/kg) | 126 ± 15 | | Ang-(1-7) and candesartan | 136 ± 16 |
| | Group 3 () | | | Ang-(1-7) (15 pmol/kg/min) | 138 ± 8 | | Candesartan (0.1 mg/kg) | 135 ± 8 | | Ang-(1-7) and candesartan | 139 ± 11 | | Ang-(1-7), candesartan, and PD123319 (50 μg/kg/min) | 139 ± 5 |
| | Group 4 () | | | Ang-(1-7) (15 pmol/kg/min) | 143 ± 10 | | Candesartan (0.1 mg/kg) | 142 ± 10 | | Ang-(1-7) and candesartan | 142 ± 9 | | Ang-(1-7), candesartan, and PD123319 (50 μg/kg/min) | 137 ± 9 |
| | Group 5 () | | | Ang-(1-7) (15 pmol/kg/min) | 128 ± 11 | | Candesartan (0.1 mg/kg) | 122 ± 10 | | Ang-(1-7) and candesartan | 133 ± 5 | | Ang-(1-7), candesartan, and A779 (15 pmol/kg/min) | 132 ± 2 |
| | Group 6 () | | | Ang-(1-7) (15 pmol/kg/min) | 129 ± 5 | | Candesartan (0.01 mg/kg) | 126 ± 10 | | Ang-(1-7) and candesartan | 132 ± 6 | | Ang-(1-7), candesartan, and A779 (15 pmol/kg/min) | 125 ± 8 |
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Values are ± SEM.
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