The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?
Figure 2
ICV delivery of (pro)renin receptor shRNA reduces brain Ang II level in the hypothalamus. The human renin and AGT double transgenic mice were ICV injected with AAV-PRR short hairpin RNA (AAV-PRR-shRNA, Vg/100nl) or control virus. Two weeks after virus injection, brain tissues were harvested for analysis of Ang II levels in the hypothalamus, cortex, and brainstem. (/group). * versus AAV-enhanced green fluorescent protein (AAV-eGFP) treatment.