Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury

Figure 3

Ischemia and reperfusion in mice with genetic deletion for the Ang-(1–7) Mas receptor (Mas^−/−) or WT mice (Mas ^+/+). Animals were subjected to 30 min of ischemia followed by 24 h of reperfusion. Serum creatinine (a), relative number of neutrophils in renal tissue (b), and number of neutrophils in blood (c) are shown as the mean ± SEM of six mice per group.

(a)

(b)

(c)