Sympathetic Nerve Activity and Baroreflex are Strongly Altered in a Context of Severe Hypertension Using the Spontaneously Hypertensive Rat Model Associated with Chronic Reduction of Nitric Oxide

Table 1

Basal and baroreflex data.

		WKY, n = 9	SHR, n = 10	SHRLN, n = 10
MBP, mmHg	Basal	151 ± 5	192 ± 4	218 ± 8^#
	Control	126 ± 3^$	142 ± 8^$	156 ± 9^$
HR, bpm	Basal	443 ± 9	401 ± 8	379 ± 10
	Control	437 ± 6	374 ± 11	355 ± 9
Diltiazem	MBP	49 ± 3	53 ± 3	60 ± 4
	Delta MBP	−77 ± 4	−89 ± 8	−96 ± 8
	HR, bpm	449 ± 12	371 ± 11	329 ± 11
L-phenylephrine	MBP	195 ± 3	226 ± 4	237 ± 10
	Delta MBP	+69 ± 5	+79 ± 8	+81 ± 13
	HR, bpm	336 ± 17	279 ± 21	329 ± 11

2-way ANOVA and Tukey’s multiple comparison test, . SHR or SHRLN versus WKY. ^#SHRLN versus SHR. Student’s t-test: ^$ control value versus basal. Basal values of mean blood pressure (MBP) and heart rate (HR) after stabilization (before surgery) and control values after surgery. Effect of diltiazem (1 mg/kg) and L-phenylephrine (20 µg/kg/min), i.v.