The Effect of Chronic and Inhospital Exposure to Renin-Angiotensin System Inhibitors on the Outcome and Inflammatory State of Coronavirus Disease 2019 Adult Inpatients

Table 3

Odds ratios for primary and secondary outcomes among RASi patients who stopped their RASi drugs during hospitalization.

	Crude model			Adjusted model
	Coef.	OR (95% CI)		Coef.	OR (95% CI)
Death	1.48	4.38 (1.11–17.21)	0.035	1.54	4.67 (0.87–24.98)	0.072
ARDS/ALI development	1.47	4.33 (1.49–12.59)	0.007	1.51	4.54 (1.53–13.44)	0.006
ICU admission	0.7	2.00 (0.73–5.47)	0.175	0.81	2.24 (0.79–6.39)	0.131
MV need	0.82	2.27 (0.53–9.72)	0.269	0.95	2.58 (0.58–11.55)	0.216

ORs and values were calculated with logistic regression analysis. Multivariable OR was adjusted for age for death and for sex for ARDS/ALI, ICU admission, and IMV need. ARDS/ALI, acute respiratory distress syndrome/acute lung injury; CI, confidence interval; Coef., logistic regression coefficient; ICU, intensive care unit; IMV, invasive mechanical ventilation; OR, odds ratio; RASi, renin-angiotensin system inhibitors.