Angiopoietin-Like Proteins 2 and 3 in Children and Adolescents with Obesity and Their Relationship with Hypertension and Metabolic Syndrome
Table 1
Anthropometric and biochemical characteristics of the children and adolescents in the control and obese groups.
Control
Obese
value
Female/male
16/19
12/23
n.s.
Age (years)
11.11 ± 2.3
11.17 ± 2.3
n.s.
BMI (Kg/m2)
18.01 ± 1.9
29.67 ± 4.9
<0.001
BMI z-score
0.14 ± 0.7
2.2 ± 0.3
<0.001
WC (cm)
67.47 ± 8.4
93.82 ± 11.3
<0.001
HC (cm)
78.03 ± 7.5
100.13 ± 10.7
<0.001
WC/HC ratio
0.85 ± 0.05
0.93 ± 0.06
<0.001
SBP (mmHg)
112.51 ± 10.28
127.37 ± 15.38
<0.001
SBP z-score
-0.13 ± 0.6
1.5 ± 0.7
<0.05
DBP (mmHg)
73.4 ± 7.7
80.46 ± 9.5
<0.001
DPB z-score
-0.2 ± 0.3
0.93 ± 1.2
n.s.
FPG (mg/dl)
86.95 ± 6.5
93.7 ± 5.5
<0.001
TG (mg/dl)
81.08 ± 39.6
105.97 ± 41.9
<0.001
TC (mg/dl)
151.68 ± 27.3
161.74 ± 25.62
n.s.
LDL-C (mg/dl)
74.08 ± 13.27
81.94 ± 16.56
<0.05
HDL-C (mg/dl)
53.17 ± 12.7
47.17 ± 8.9
<0.05
Insulin (µIU/dl)
6.5 ± 3.1
14.05 ± 9.3
<0.001
HOMA-IR
1.4 ± 0.7
3.2 ± 2.17
<0.001
ANGPTL2 (ng/ml)
7.6 (6.2–10.03)
10.32 (9.53–11.42)
<0.001
ANGPTL3 (ng/ml)
198.82 (142.2–233.2)
256.48 (219.7–311.8)
<0.0001
Data are presented as mean ± standard deviation (SD) for parametric variables and median (interquartile range) for nonparametric variables. BMI : body mass index; WC : waist circumference; HC : hip circumference; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; TG: triglycerides; TC: total cholesterol; LDL-C : low-density lipoprotein cholesterol; HDL-C : high-density lipoprotein cholesterol; HOMA-IR : homeostasis model assessment-insulin resistance; ANGPTL: angiopoietin-like protein; n.s.: nonsignificant.
