Disturbances of the Gut Microbiota, Sleep Architecture, and mTOR Signaling Pathway in Patients with Severe Obstructive Sleep Apnea-Associated Hypertension

<div>Profiles of differentially expressed gene transcripts between control patients without obstructive sleep apnea (non-OSA; apnea-hypopnea index (AHI) ≤5 without hypertension) and patients with OSA and hypertension (OSA-HTN; AHI ≥30). (a) Hierarchical heat maps, (b) volcano plots, and (c) top 20 overrepresented Kyoto Encyclopedia of Genes and Genomes pathways of the common differentially expressed genes. The colors (red, orange, green, light blue, and purple) represent the <i>Q</i> value (i.e., the lowest false discovery rate), whereas the variably sized dots represent the number of genes involved in each pathway.</div>

International Journal of Hypertension

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Figure 2

Figure 2: Disturbances of the Gut Microbiota, Sleep Architecture, and mTOR Signaling Pathway in Patients with Severe Obstructive Sleep Apnea-Associated Hypertension 

Figure 2 | Disturbances of the Gut Microbiota, Sleep Architecture, and mTOR Signaling Pathway in Patients with Severe Obstructive Sleep Apnea-Associated Hypertension 