Syndecan-4 is More Sensitive in Detecting Hypertensive Left Ventricular Diastolic Dysfunction in 2K2C Rats
Table 1
General Clinic and Echocardiographic Findings in rats.
Time (week)
4 w
8 w
12 w
Sham (n = 5)
2K2C (n = 7)
Sham (n = 5)
2K2C (n = 7)
Sham (n = 5)
2K2C (n = 7)
SBP (mmHg)
122.4 ± 2.3
126.3 ± 3.5
117.7 ± 3.2
161.7 ± 6.2
118.9 ± 3.0
201.8 ± 9.2
Weight (g)
335 ± 21
360 ± 46
440 ± 14
439 ± 15
521 ± 17
518 ± 17
BSA (m2)
0.044 ± 0.002
0.046 ± 0.004
0.053 ± 0.001
0.053 ± 0.001
0.059 ± 0.001
0.059 ± 0.001
LAd (mm)
2.87 ± 0.2
2.62 ± 0.3
3.38 ± 0.2
3.14 ± 0.4
3.43 ± 0.2
3.27 ± 0.3
IVSd (mm)
1.45 ± 0.1
1.73 ± 0.1
1.50 ± 0.0
1.99 ± 0.1#
1.48 ± 0.0
2.50 ± 0.1#
LVDd (mm)
5.95 ± 0.2
5.93 ± 0.4
6.90 ± 0.5
6.37 ± 0.3
6.78 ± 0.4
6.68 ± 0.8
LVDs (mm)
3.45 ± 0.2
3.93 ± 0.4
4.30 ± 0.7
3.97 ± 0.3
4.31 ± 0.3
4.25 ± 0.5
LVPWd (mm)
1.40 ± 0.0
1.63 ± 0.1
1.45 ± 0.1
1.91 ± 0.0#
1.46 ± 0.0
2.32 ± 0.2#
LVM (mg)
392.87 ± 35.9
498.10 ± 69.8
522.66 ± 52.6
687.67 ± 50.6#
504.68 ± 48.8
1033.97 ± 265.8#
LVMI (g/m2)
8.9 ± 0.4
10.9 ± 1.7
9.9 ± 1.2
13.1 ± 0.9#
8.6 ± 0.9
17.6 ± 4.4#
EF (%)
78.5 ± 2.1
68.7 ± 5.5
73.0 ± 5.7
73.9 ± 2.7
72.0 ± 3.6
71.8 ± 4.0
FS (%)
42.0 ± 2.8
33.7 ± 4.5
37.5 ± 5.0
37.9 ± 2.1
36.0 ± 3.1
36.0 ± 3.2
SBP, indicates systolic blood pressure; BSA, body surface area; LAd, left atrial diameter; IVSd, end-diastolic interventricular septum thickness; LVDd, end-diastolic left ventricular internal diameters; LVDs, end-systolic left ventricular internal diameters; LVPWd, end-diastolic left ventricular posterior wall thickness; LVM, left ventricular mass; LVMI, left ventricular mass index; EF, ejection fraction; FS, fractional shortening. Data are presented as the mean ± standard deviations from each group. #is and is vs. rats in the sham group.
