Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan

Table 2

Genotype distribution and allele frequency of AGTR1 A1166C and CYP2C9∗3 in well-controlled group (n = 144) and poorly controlled group (n = 137).

	Genotypes, n (%)				Alleles, n (%)
AGTR1 A1166C	AA	AC	CC	P^a	A	C
Well-controlled	119 (82.6)	24 (16.7)	1 (0.7)	0.006	262 (91.0)	26 (9.0)	0.005
Poorly controlled	128 (93.4)	9 (6.6	0 (0)		265 (96.7)	9 (3.3)
CYP2C9∗3	∗1/∗1	∗1/∗3	∗3/∗3	P^b	∗1	∗3
Well-controlled	134 (93.1)	10 (6.9)	0 (0)	0.239	278 (96.5)	10 (3.5)	0.250
Poorly controlled	122 (89.1)	15 (10.9)	0 (0)		259 (94.5)	15 (5.5)

^a value was calculated for comparison between genotype AA and AC + CC using Chi-square test. ^b value was calculated for comparison between genotype ∗1/∗1 and ∗1/∗3 using chi-square test.