Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention

Figure 19

Immunohistochemistry of β-catenin, COX-2, iNOS, and p53 in the colonic adenocarcinoma and dysplastic crypts developed in male Apc^{Min /+} mice that received 2% DSS (upper panel). Apc allelic loss and gene mutations of β-catenin and K-ras in the colonic adenocarcinoma from male Apc^Min/+  mice (lower panel).