Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention

Figure 4

Chemical structure of dextran sulfate sodium (DSS), a sulfated polysaccharide, and its biological activities. DSS (1–5% in drinking water or diet) induces colitis in rodents. Treatment with DSS (1% in diet) after DMH exposure produces colonic adenocarcinoma [44]. The tumorigenicityof DSS is non-genotoxic effects [20]. Cycle treatment with 3% DSS (MW 54,000, 7 days) and distilled water (14 days) produces colonic tumors [45]. DSS increases the number of ACF induced by AOM [19].