Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention

Table 2

Animal models of colorectal carcinogenesis and inflammatory bowel disease. HCAs: heterocyclic amines.

(1) Animal models of colorectal carcinogenesis
(i) Carcinogen-induced animal models
Azoxymethane (AOM)
1,2-Dimethyl-hydrazine (DMH)
HCAs: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
2-Amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx)
(ii) Mutant, transgenic, knockout animal models
Min mouse and APC^Δ474 knockout mouse
(2) Animal models of inflammatory bowel disease
(i) Chemically and polymer-induced models
Trinitrobenzene sulfonic acid (TNBS): rat, mouse, rabbit
Dextran sulfate sodium (DSS): rat, mouse, hamster
Carrageenan: mouse, guinea pig, rabbit
(ii) Microbial-induced models
Cotton-top tamarins (Saguinus oedipus)
(iii) Mutant mice
IL-2^−/−, IL-10^−/−, TCR-α ^−/−, TCR-β ^−/−