Methylation Pattern of the SOCS3 and IL6R Promoters in Rheumatoid Arthritis

Table 2

Characteristics of patients with rheumatoid arthritis and healthy controls enrolled to the study.

Characteristics	RA overall, n = 122	HC, n = 24	value
Age (years)	52.2 ± 12.3	52.9 ± 8.6	0.99
Females; n (%)	103 (84.4)	18 (75)	0.41
Disease duration (years)	10 [3–16]	n/a	n/a
RF-positive; n (%),	82 (67.2)	None	n/a
ACPA-positive; n (%)	104 (85.2)	None	n/a
ESR	26 [8–57.5]	15 [7–19]	0.001
CRP (mg/dl)	8.54 [0.53–19.12]	0.58 [0.19–1.97]	<0.0001
DAS28	3.95 ± 1.55	n/a	n/a
Swollen joints	1 [0–4]	n/a	n/a
Tender joints	3 [1–6]	n/a	n/a
VAS PGA	27 [9–61]	n/a	n/a
VAS PhGA	20 [7–49]	n/a	n/a

Data are presented as mean ± SD, number (percentage), or median [interquartile range]. ACPA, anticitrullinated protein antibodies; DAS28, disease activity score 28; CRP, C-reactive protein; cDMARD, classical disease-modifying antirheumatic drugs; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor; VAS PhGA, visual analog scale physician global assessments; VAS PGA, visual analog scale patient global assessments.