Review Article
OMICS Approaches Evaluating Keloid and Hypertrophic Scars
Table 4
Transcriptomic study of differentially regulated genes in keloids, hypertrophic scars, and normal skin.
| Gene | Keloids | Hypertrophic scars | Normal skin |
| −1 chain of collagen XI | ↑ [62] | ⟶ | | α − 2 chain of collagen type 5 | ↑ [62] | ⟶ | | Pro (α − 1) chain of collagen type 3 | ↑ [62] | ⟶ | | Pro (α − 2) chain of collagen type 1 | ↑ [62] | ⟶ | | α − 1 chain of collagen type 4 | ↑ [62] | ⟶ | | Fibronectin | ↑ [62] | ⟶ | | Nerve growth factor (NGF) | ↑ [62] | ⟶ | | TGF-β1 | ↑ [62] | ⟶ | | VEGF165 receptor | ↓ [62] | ͢ | | ASK1 | | ⟶ | ↑ compared to KL | KIAA0018 | | ⟶ | ↑ compared to KL | p21 | | ⟶ | ↓ compared to KL | ACAN | ↑ [63] | ⟶ | | COL1A1 | ↑ [63] | ⟶ | | COL1A2 | ↑ [63] | ⟶ | | COL4A2 | ↑ [63] | ⟶ | | COL5A2 | ↑ [63] | ⟶ | | COL6A1 | ↑ [63] | ⟶ | | COL15A1 | ↑ [63] | ⟶ | | FN1 | ↑ [63] | ⟶ | | OGN | ↑ [63] | ⟶ | | POSTN | ↑ [63] | ⟶ | | TGF-βriii | ↓ [63] | ⟶ | | VCAN | ↑ [63] | ⟶ | | ANXA1 | ↑ [63] | ⟶ | | EGFR | ↓ [63] | ⟶ | | HIF-1A | ↑ [63] | ⟶ | | SERPINF1 | ↓ [63] | ⟶ | | CNR1 | ↓ [64] | ⟶ | | HOXA5, HOXA7, HOXC11 | ↓ [64] | ⟶ | | HIST1H1A, HIST1H1B, HIST1H2BH, and HIST1H4F | ↑ [64] | ⟶ | | ASF1B | ↑ [64] | ⟶ | | Proteins K and H | ↑ [64] | ⟶ | | HAS2 | ↑ [64] | ⟶ | | KRT7 | ↑ [64] | ⟶ | | LOXL2 | ↑ [64] | ⟶ | | KRT1 | ↓ [64] | ⟶ | | KRT16 | ↓ [64] | ⟶ | | CDH11 | ↑ [64] | ⟶ | | VIM | ↑ [64] | ⟶ | | α-smooth muscle actin | ⟶ | ↑ [65] | | Tropomyosin TM30 | ⟶ | ↑ [65] | | Vimentin | ⟶ | ↑ [65] | | Profilin | ⟶ | ↑ [65] | | BM40 | ⟶ | ↑ [65] | | Quinoline phosphoribosyltransferase | ⟶ | ↑ [66] | | Serine (or cysteine) proteinase inhibitor clade B | ⟶ | ↑ [66] | | Collagen type XIII α − 1 | ⟶ | ↑ [66] | | Plasminogen activator urokinase | ⟶ | ↑ [66] | | Neuromedin | ⟶ | ↑ [66] | | Stromal cell derived factor −1, serine protease 23 | ⟶ | ↓ [66] | | Pregnancy specific β glycoprotein 7 | ⟶ | ↓ [66] | | Tubulin-α − 1 | ⟶ | ↓ [66] | | Cardiac actin gene | ⟶ | ↓ [66] | |
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