Research Article
In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)
Table 2
Effect of hydroethanolic extract of V. guineensis on cyclooxygenase, 5-lipoxygenase, protein denaturation, proteanase, and membrane stabilisation.
| | Concentration (µg/ml) | Inhibition (%) | COX | 5-LOX | Protein denaturation | Proteinase | Membrane stabilisation |
| Iburprofen | 50 | 51.90 ± 1.29 | 43.02 ± 1.90 | — | — | — | 100 | 63.10 ± 1.21 | 56.21 ± 0.76 | — | — | — | 200 | 78.11 ± 0.33 | 66.34 ± 1.19 | — | — | — | 400 | 82.21 ± 0.22 | 73.71 ± 1.01 | — | — | — |
| Diclofenac | 50 | — | — | 40.22 ± 0.89 | 52.55 ± 1.23 | 56.32 ± 1.34 | 100 | — | — | 59.01 ± 1.21 | 68.03 ± 1.09 | 67.62 ± 0.29 | 200 | — | — | 70. 32 ± 0.23 | 75.21 ± 1.92 | 73.01 ± 1.89 | 400 | — | — | 83.88 ± 2.01 | 81.02 ± 1.12 | 83.90 ± 1.11 |
| Hydroethanolic extract | 50 | 50.10 ± 0.32 | 35.33 ± 0.21 | 44.51 ± 1.34 | 49.90 ± 1.22 | 46.52 ± 0.27 | 100 | 62.19 ± 0.82 | 41.23 ± 0.39 | 59.20 ± 1.10 | 61.11 ± 2.01 | 59.99 ± 0.26 | 200 | 73.29 ± 0.19 | 53.22 ± 0.98 | 67.01 ± 1.34 | 70.71 ± 1.01 | 73.27 ± 1.30 | 400 | 80.19 ± 0.13 | 64.66 ± 1.11 | 79.02 ± 0.81 | 83. 88 ± 1.11 | 80.57 ± 1.02 |
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The percentage values were obtained using various concentrations of test compounds and readings are presented as the mean of triplicates.
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