Research Article
In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)
Table 3
General appearance and behavioral observations of acute toxicity study after hydroethanolic extract of V. guineensis administration.
| Observation | After 4 hours | After 7 days | Distilled water | 250 mg/kg | 2500 mg/kg | 5000 mg/kg | 250 mg/kg | 2500 mg/kg | 5000 mg/kg |
| Alertness | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Body weight | Normal | Not change | Not change | Not change | Not change | Not change | Not change | Grooming | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Temperature | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Restlessness | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Touch response | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Food intake | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Pain response | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Urination | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Righting reflux | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Pinna reflex | Present | Present | Present | Present | Present | Present | Present | Writhing | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Tremors | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Salivation | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Convulsion | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Corneal reflex | Present | Present | Present | Present | Present | Present | Present | Lacrimation | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Water intake | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Rate of respiration | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Gripping | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Skin color | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Drowsiness | Not present | Not present | Not present | Present | Not present | Not present | Not present | Pupils | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Sedation | No effect | No effect | No effect | Observed | No effect | No effect | No effect | Eye color | No effect | No effect | No effect | No effect | No effect | No effect | No effect | Diarrhea | Not present | Not present | Not present | Not present | Not present | Not present | Not present | General physique | Normal | Normal | Normal | Lethargy | Normal | Normal | Normal | Mortality | Nil | Nil | Nil | Nil | Nil | Nil | Nil |
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