In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)
Table 5
Effect of the hydroethanolic extract of V. guineensis on some serum parameters.
Treatment
Dose (mg/kg)
ALT (μ/I)
AST (μ/I)
ALP (μ/I)
Creatinine (mg/ml)
Protein (g/dl)
Normal control
—
119.30 ± 2.86
421.90 ± 18.65
226.80 ± 2.70
0.38 ± 0.03
6.76 ± 0.51
Negative control
—
205.10 ± 7.04λ
464.70 ± 11.97
354.20 ± 5.79λ
0.43 ± 0.08
3.76 ± 0.24λ
Diclofenac
5
156.00 ± 5.37βc
455.50 ± 12.15
328.10 ± 4.68β
0.41 ± 0.06
5.31 ± 0.23
Hydroethanolic extract
62.5
207.60 ± 8.47λ
462.40 ± 14.23
346.50 ± 15.33λ
0.43 ± 0.05
3.96 ± 0.16β
125
150.00 ± 8.91αc
454.30 ± 13.77
268.30 ± 25.81a
0.39 ± 0.03
5.94 ± 0.33b
250
134.30 ± 3.46c
439.20 ± 24.98
244.00 ± 5.63b
0.38 ± 0.03
6.70 ± 0.27b
Each value represents the mean ± SEM of 5 animals. ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. a,b, and c are statistically significant compared to negative control; α,β, and λ are statistically significant compared to the neutral control.