The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PE/PPE-Related Drug Targets

Table 4

Current evidence linking genes identified in this study to   M. tuberculosis  persistence.

ORF	Gene	Existing Evidence
Rv2657c	—	Unknown
Rv2374c	hrcA	Required for survival in primary murine macrophage [19]
		Regulation of heat-shock proteins
Rv0354c	PPE7	Downregulated after 96 hours of starvation [20]
Rv1364c	—	Unknown
Rv2304c	—	Unknown
Rv0367c	—	Upregulated at high temperatures [21]
Rv0607	—	Essential gene [22]
Rv2466c	—	Upregulated at high temperatures [21]
Rv0830	—	Unknown
Rv2557	—	Upregulated after 24 hours and 96 hours of starvation [20]
		Expression in human lung granulomas [23]
Rv2142c	—	Unknown
Rv0654	—	Upregulated at high temperatures [21]
Rv1977	—	Unknown
Rv2688c	—	Unknown
Rv1285	cysD	Upregulated at high temperatures [21]
		Upregulated after 24 hours of starvation [20]
Rv0047c	—	Unknown
Rv2878c	mpt53	Unknown
Rv2254c	—	Unknown
Rv1986	—	Unknown
Rv2777c	—	Upregulated at high temperatures [21]
Rv2413c	—	Upregulated after 4 hours of starvation [20]
Rv1929c	—	Upregulated after 96 hours of starvation [20]
Rv3288c	usfY	Upregulated after 24 hours and 96 hours of starvation [20]
Rv2535c	PEPQ	Impaired growth [22]
Rv2634c	PE_PGRS46	Unknown
Rv1646	PE17	Unknown
Rv2749	—	Unknown
Rv3452	cut4	Unknown
Rv0192	—	Unknown
Rv1687c	—	Unknown
Rv1087	PE_PGRS21	Unknown
Rv1566c	—	Unknown
Rv2504c	scoA	Involved in fatty acid degradation and synthesis [24]
Rv0834c	PE_PGRS14	Unknown
Rv0274	—	Upregulated after 4 hours, 24 hours and 96 hours of starvation [20]
Rv2162c	PE_PGRS38	Unknown
Rv0365c	—	Involved in survival in macrophages [19]
Rv3550	ECHA20	Fatty acid degradation [24]
Rv3367	PE_PGRS51	Upregulated after 96 hours of starvation [20]
Rv2802c	—	Unknown
Rv2291	sseB	Unknown
Rv3189	—	Unknown