Research Article
Novel Microdilution Method to Assess Double and Triple Antibiotic Combination Therapy In Vitro
Table 5
Summary of the outcome of double and triple combinations of the antibiotics.
| | Antibiotic combination | Number/type of interactions | | Synergism | Antagonism | Indifference |
| | CIP + AMK | 0 | 0 | 10 | | CIP + CAZ | 1 | 0 | 9 | | CIP + PIP | 2 | 0 | 8 | | CIP + IMP | 0 | 0 | 10 | | IMP + PIP | 0 | 2 | 8 | | AMK + CAZ | 4 | 0 | 6 | | AMK + IMP | 0 | 0 | 10 | | AMK + PIP | 2 | 0 | 8 | | CAZ + IMP | 0 | 3 | 7 | | CAZ + PIP | 4 | 0 | 6 | | CIP + AMK + CAZ | 10 | 0 | 0 | | CIP + AMK + PIP | 7 | 0 | 3 | | CIP + AMK + IMP | 4 | 0 | 6 | | CIP + CAZ + PIP | 4 | 0 | 6 | | CIP + CAZ + IMP | 1 | 0 | 9 | | CIP + PIP + IMP | 1 | 0 | 9 | | AMK + CAZ + PIP | 8 | 0 | 2 | | AMK + CAZ + IMP | 4 | 0 | 6 | | CAZ + PIP + IMP | 2 | 0 | 8 |
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CIP, ciprofloxacin; AMK, amikacin; CAZ, ceftazidime; PIP, piperacillin; IMP, imipenem.
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