Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)

<div>Pairwise antibiotic testing against MRSA. (a) List of pairwise combinations. (b) MIC by broth microdilution indicates that synergistic relationship exists between moxifloxacin and lower-generation cephalosporin (FICI 0.14–0.265). (c) Levofloxacin-ceftazidime shows FICI value as low as 0.281 indicating synergy. (d) Meropenem demonstrates synergy with higher generation of fluoroquinolones, i.e., moxifloxacin (FICI 0.132) and sparfloxacin (FICI 0.265). (e) Imipenem shows collateral sensitivity with all fluoroquinolones (FICI 0.126 each).</div>

International Journal of Microbiology

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Figure 1

Figure 1: Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) 

Figure 1 | Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) 