Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)

<div>Time-Kill kinetics on antibiotics individually and collaterally. (a) Levofloxacin-ceftazidime combination with 8-fold growth reduction compared to most active monotherapy. (b) &lt;2-log 10 difference in killing with amoxicillin-clavulanic acid-cephradine combination therapy compared to most active single treatment shows lack of synergy. (c) Amoxicillin-clavulanic acid-ofloxacin combination is collaterally indifferent as decrease in bacterial growth is &lt;2-log 10. (d) Amoxicillin-clavulanic acid-tobramycin combination shows synergy because of &gt;2-log 10 growth reduction. (e) Collateral sensitivity is shown in piperacillin-tazobactam-tobramycin combination.</div>

International Journal of Microbiology

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Figure 3

Figure 3: Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) 

Figure 3 | Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) 