Clinical Accuracy of Instrument-Read SARS-CoV-2 Antigen Rapid Diagnostic Tests (Ag-IRRDTs)

Table 3

Comparison of two systematic review studies. Our study presenting only instrument-read rapid antigen tests is compared and contrasted with another review⁴ that included only rapid antigen tests which does not employ any reader equipment. Positive sample counts are those tests that were confirmed by qRT-PCR.

Property	Ag-RDTs	Ag-IRRDTs
Reference	Hayer et al. [5]	This study
Number of datasets	19	48
Number of samples	11,109	137,770
Number of manufacturers	5	11
As of date:	20.11.2020	30.09.2021
Positive sample count	2,509	5,925
Sensitivity min. %	28.9	22.9
Sensitivity min. 95% CI	16.4–44.3	15.2–33.0
Sensitivity max. %	98.3	96.4
Sensitivity max. 95% CI	91.1–99.7	82.3–99.4
Specificity min.%	92.4	85.6
Specificity min. 95% CI	87.4–95.9	79.0–90.4
Specificity max.%	100.0	100.0
Specificity max. 95% CI	99.7–100.0	98.0–100.0
Max. pooled sensitivity, %	82.4	87.2
Max. pooled sens., 95% CI	87.4–95.9	81.2–91.3
Pooled sensitivity, %	74.7	67.1
Pooled sens., 95% CI	67.3–80.9	65.9–68.3
Min.-max. Prevalence, %	1.9–100	0.4–78.7
Higgins’ I^2%	93	10.75