Angiotensin-Converting Enzyme-2 (ACE-2) with Interferon-Induced Transmembrane Protein-3 (IFITM-3) Genetic Variants and Interleukin-6 as Severity and Risk Predictors among COVID-19 Egyptian Population

Table 4

Genotypes and allelic frequencies of ACE-2 (rs2285666) and IFITM-3 (rs12252) among the studied cases regarding COVID-19 severity.

SNPs	Mild/moderate (n = 40)		Severe (n = 60)		Critical (n = 60)		Control (n = 40)
	No.	%	No.	%	No.	%	No.	%
rs2285666
Genotype
C\C	30	75.0	12	20.0	8	13.3	30	75.0	<0.001
C\T	6	15.0	16	26.7	20	33.3	8	20.0
T\T	4	10.0	32	53.3	32	53.3	2	5.0
0	^MC		<0.001		<0.001
Sig. bet. grps.	, ,
Allele
C	66	82.5	40	33.3	36	30.0	68	85.0	<0.001
T	14	17.5	80	66.7	84	70.0	12	15.0
0	0.668		<0.001		<0.001
Sig. bet. grps.	, ,
rs12252
Genotype
A\A	28	70.0	12	20.0	11	18.3	30	75.0	<0.001
A\G	10	25.0	12	20.0	24	40.0	8	20.0
G\G	2	5.0	36	60.0	25	41.7	2	5.0
0	^MC
Sig. bet. grps.	, ,
Allele
A	66	82.5	36	30.0	46	38.3	68	85.0	<0.001
G	14	17.5	84	70.0	74	61.7	12	15.0
0	0.668		<0.001		<0.001
Sig. bet. grps.	, ,

C\C, A\A: wild genotype. A\G, C\T: hetero genotype. G\G, T\T: mutant genotype. MC: Monte Carlo. χ²: Chi square test. ₀: value for the Chi square test for comparing between control and each other groups. ₁: value for the Chi square test for comparing between mild/moderate and severe. ₂: value for the Chi square test for comparing between mild/moderate and critical. ₃: value for the Chi square test for comparing between severe and critical. Statistically significant at .