Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients

Table 3

Mutations and amino acid substitutions in the PreC-C region.

Region	Mutation	aa substitution	Mutation possible effect	Reference
PreC; (1814–1900 nt)	G1899A	G29D	HCC	[24]
Core; (1901–2452 nt)	G1985C	D29H	U	[25]
	A2092T	E64D	CHB	[26]
	T2121G	V74G	HCC	[26]
	G2129C	E77Q	CHB	[26]
	G2138A	A80T	CHB	[26]
	G2140A	A80I	U	Current study
	A2174C	N92H	U	Current study
	C2289A	P130Q	HCC	[26]
	T2363A	S155T	U	[26]

Bold font mutation: indicated known referenced mutation, aa: amino acid, CHB: chronic hepatitis, HCC: hepatocellular carcinoma, U: uncharacterized effect.