Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome

Table 1

List of identified genes/proteins, number of articles identified for cardiorenal, and relative expression levels based on UniGene EST counts for blood, heart, vascular, and kidney, and tissue showing maximum expression of a specific feature.

Symbol	Articles	Expression in blood (%)	Expression in heart (%)	Expression in vascular (%)	Expression in kidney (%)	Max. expression (%)
REN	156	0	0	0	19,27	39,58	intestine
NPPA	122	88,04	0	0	0	88,04	heart
AGT	64	1,79	18,54	0	5,71	29,74	liver
ADM	55	0,95	1,38	1,09	3,11	15,3	adipose tissue
ACE	39	0,86	2,37	4,09	4,53	15,63	parathyroid
EDN1	39	0	4,12	15,82	2,77	32,68	umbilical cord
NPPB	31	85,93	0	0	1,2	85,93	heart
RAPGEF5	28	0	0	0	0,76	76,62	parathyroid
NOS3	27	3,92	2,69	2,33	2,2	20,32	spleen
EPO	22	0	0	0	0	58,82	prostate
CNP	21	0,85	1,74	3,58	5,4	18,03	brain
TGFB1	20	8,67	0,99	0	1,79	17,67	salivary gland
MME	19	0,26	3,59	0	11,63	12,06	lymph node
PTGS2	19	16,39	0	29,1	0,59	29,1	vascular
INS	18	0	0	0	0	100	pancreas
NPR1	17	0	1,32	2,29	2,83	23,69	mammary gland
NOS2	13	4,23	0	0	0	25,4	pharynx
DDR1	13	0	0,94	0	0,46	20,12	trachea
KNG1	10	0	0	0	33,18	57,18	liver
PLEK	10	11,02	0,34	1,77	0,87	16,81	lymph
NCF1	10	10,88	0	0	0,76	32,38	lymph node
HESX1	10	0	0	0	0	43,18	ovary
FOS	9	19,04	2,09	4,31	0,77	19,04	blood
CALCA	9	0	0	0	0	100	prostate
S100A6	9	1,2	0,87	5,16	1,18	20,08	umbilical cord
NOS1	8	0	0	0	1,68	65,97	muscle
AVP	8	0	0	0	80	80	kidney
RHOA	7	2,5	1,57	2,02	1,72	5,28	cervix
CYBB	7	19,44	0	2,55	3,15	27,68	lymph node
MAPK1	7	1,84	1,35	2,36	1,44	10,94	mouth
AKT1	7	1,14	1,57	0,45	1,51	13,52	salivary gland
ICAM1	7	3,19	0,55	2,39	1,62	15,19	spleen
CALCRL	7	0	2,55	14,85	1,39	25,06	trachea
SERPINE1	7	0,17	0,12	14,5	0,69	27,77	umbilical cord
EDNRA	7	0	6,4	2,21	1,63	10,94	uterus
SHBG	7	0	0	0	0	36,84	eye
RAMP2	7	5,09	0	0	1,85	28,7	thyroid
UTS2	7	0	0	0	3,88	35,92	spleen
OLR1	6	1,23	0	0	2,15	81,05	esophagus
AGTR1	6	0	5,19	0	3,3	19,1	larynx
NFKB1	6	4,69	0,76	0,66	1,62	8,69	nerve
UTS2R	6	0	0	0	0	100	ovary
NR3C2	6	0	0	6,41	7,08	20,74	stomach
EPHB2	6	6,73	0	0	2,85	14,78	umbilical cord
ISYNA1	6	1,49	0,43	0,52	3,31	17,72	umbilical cord
GPR182	5	0	0	0	0	38,67	adrenal gland
COX8A	5	0,77	11,02	1,48	0,98	11,02	heart
CPOX	5	9,24	3,63	0	5,28	11,06	liver
EGFR	5	0	2,2	1,69	2,49	14,89	mouth
COX5A	5	0	0	0	0	100	muscle
CCL2	5	0	0	0	0	100	placenta
PPARG	5	0	1,46	2,52	3,72	12,08	placenta
CYBA	5	2,25	6,82	1,67	3,43	15,46	tonsil
RAMP3	5	7,76	0	0	2,54	21,44	adipose tissue