Mechanisms of Glomerular Albumin Filtration and Tubular Reabsorption

Table 1

Comparison of the glomerular albumin-sieving coefficient (SC) values.

Authors, year	Method	SC	Species/animal model
Tojo and Endou [12], 1992	Fractional micropuncture	0.00062	rat
Bertolatus and Hunsicker [62], 1985	^131I-labeled BSA measuring urinary excretion and total kidney uptake minus interstitial nonfiltration uptake	0.0006	rat
		0.021	hexadimethrine nephrotic rat
		0.025	adriamycin nephrotic rat
	^131I-labeled neutral BSA	0.026	rat
Lund et al. [18], 2003	^125I-native human serum albumin measuring both kidney uptake and urinary excretion	0.00066	rat
	^125I-neutral human serum albumin	0.0065	rat
Norden et al. [13], 2001	urinary albumin excretion of congenital Fanconi syndrome patients	0.00008	human
Tencer et al. [63], 1998	Blockade of proximal tubular reabsorption by L-lysine	0.00033	rat
		0.0591	puromycin aminonucleoside nephrotic rat
Ohlson et al. [64], 2000	Inhibition of tubular function by cooling (8°C)	0.0019	rat
Christensen et al. [23], 2007	urinary albumin excretion of megalin-knockout mice	0.00016	megalin-knockout mice
Eppel et al. [14], 1999	tritium-labeled albumin	0.074	rat
Russo et al. [15], 2007	Alexa-labeled albumin, confocal microscopy	0.0341	rat
Tanner [16]	Alexa-labeled rat serum albumin, two-photon microscope with internal photodetectors	0.002	Munich-Wistar rat