Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats

<table>Expression of ICAM-1 and VCAM-1 mRNA in HUVECs. Expressions of adherence factors; ICAM-1 and VCAM-1 mRNA were examined to clarify the effect of IS on synthesis of HUVECs<i> in vitro</i> (<svg height="10.925" id="M20" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). Both syntheses of ICAM-1 and VCAM-1 mRNA were accelerated by IS in dose-dependent manner. <svg height="13.95" id="M21" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to the control group. <svg height="13.95" id="M22" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 81.462502 13.95" width="81.462502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to the control group.</table>

International Journal of Nephrology

fig5

Figure 5

Figure 5: Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats 